Type 2 diabetes mellitus has been at the forefront of human diseases and phenotypes
studied by new genetic analyses. Thanks to genome‐wide association studies, we have …

To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …

OBJECTIVE—There is considerable interindividual variation in sulfonylurea response in
type 2 diabetes. Transcription factor 7-like 2 (TCF7L2) variants have been identified to be …

Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …

Diabetes mellitus affects approximately 382 million individuals worldwide and is a leading
cause of morbidity and mortality. Over 40 and nearly 80 genetic loci influencing susceptibility …

Abstract Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …

Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin
resistance and progressively reduced insulin secretion, which leads to impaired glucose …

The sulfonylureas stimulate insulin release from pancreatic β cells, and have been a
cornerstone of Type 2 diabetes pharmacotherapy for over 50 years. Although sulfonylureas …

OBJECTIVE—The purpose of this study was to investigate whether genetic variants could
influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients. RESEARCH …

A variety of treatment modalities exist for individuals with type 2 diabetes mellitus (T2D). In
addition to dietary and physical activity interventions, T2D is also treated pharmacologically …