Fluoride contamination, health problems and remediation methods in Asian groundwater: A comprehensive review

KK Yadav, S Kumar, QB Pham, N Gupta… - Ecotoxicology and …, 2019 - Elsevier
Highlights•The status of fluoride contamination in groundwater of Asian countries is
reviewed.•India, Pakistan and China are critically affected by fluoride contamination.•Dental …

Molecular mechanisms of fluoride toxicity

O Barbier, L Arreola-Mendoza, LM Del Razo - Chemico-biological …, 2010 - Elsevier
Halfway through the twentieth century, fluoride piqued the interest of toxicologists due to its
deleterious effects at high concentrations in human populations suffering from fluorosis and …

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach

JV Castell, MT Donato, MJ Gómez-Lechón - Experimental and Toxicologic …, 2005 - Elsevier
Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is
frequently exposed to elevated concentrations of these compounds and become the primary …

Molecular mechanisms of cytotoxicity and apoptosis induced by inorganic fluoride

NI Agalakova, GP Gusev - International Scholarly Research …, 2012 - Wiley Online Library
Fluoride (F) is ubiquitous natural substance and widespread industrial pollutant. Although
low fluoride concentrations are beneficial for normal tooth and bone development, acute or …

Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation

K Kubota, DH Lee, M Tsuchiya, CS Young… - Journal of Biological …, 2005 - ASBMB
The mechanism of how fluoride causes fluorosis remains unknown. Exposure to fluoride can
inhibit protein synthesis, and this may also occur by agents that cause endoplasmic …

Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons

M Zhang, A Wang, W He, P He, B Xu, T Xia, X Chen… - Toxicology, 2007 - Elsevier
The mechanisms underlying the neurotoxicity of endemic fluorosis still remain unknown. To
investigate the expression level of neural cell adhesion molecules (NCAM), oxidative stress …

Involvement of both mitochondrial-and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human …

JH Lee, JY Jung, YJ Jeong, JH Park, KH Yang… - Toxicology, 2008 - Elsevier
Sodium fluoride (NaF) has been shown to be cytotoxic and produces inflammatory
responses in humans. However, the cellular mechanisms underlying the NaF-induced …

[HTML][HTML] DNA damage, apoptosis and cell cycle changes induced by fluoride in rat oral mucosal cells and hepatocytes

LF He, JG Chen - World journal of gastroenterology: WJG, 2006 - ncbi.nlm.nih.gov
AIM: To study the effect of fluoride on oxidative stress, DNA damage and apoptosis as well
as cell cycle of rat oral mucosal cells and hepatocytes. METHODS: Ten male SD rats …

Fluorescent probe for detection of fluoride in water and bioimaging in A549 human lung carcinoma cells

SY Kim, J Park, M Koh, SB Park, JI Hong - Chemical communications, 2009 - pubs.rsc.org
Fluorescent probe for detection of fluoride in water and bioimaging in A549 human lung
carcinoma cells - Chemical Communications (RSC Publishing) DOI:10.1039/B908745A Royal …

Antioxidant phytochemicals for the prevention of fluoride-induced oxidative stress and apoptosis: A review

LM Angwa, Y Jiang, J Pei, D Sun - Biological Trace Element Research, 2022 - Springer
Fluorosis is a major public health problem globally. The non-availability of specific treatment
and the irreversible nature of dental and skeletal lesions poses a challenge in the …