Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Mitochondrial superoxide production is an important source of reactive oxygen species in
cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites …

The free radical theory of aging postulates that the production of intracellular reactive
oxygen species is the major determinant of life span. Numerous cell culture, invertebrate …

Life is the interplay between structure and energy, yet the role of energy deficiency in human
disease has been poorly explored by modern medicine. Since the mitochondria use …

Several mitochondrial proteins are tumor suppressors. These include succinate
dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) …

The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the
mitochondrial respiratory complex II, has been determined, revealing the electron transport …

The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

A mild inhibition of mitochondrial respiration extends the life span of many organisms,
including yeast, worms, flies, and mice [1–10], but the underlying mechanism is unknown …