Click chemistry and radiochemistry: an update
The term “click chemistry” describes a class of organic transformations that were developed
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …
[HTML][HTML] Molecular imaging of apoptosis: the case of caspase-3 radiotracers
L Beroske, T Van den Wyngaert, S Stroobants… - International journal of …, 2021 - mdpi.com
The molecular imaging of apoptosis remains an important method for the diagnosis and
monitoring of the progression of certain diseases and the evaluation of the efficacy of …
monitoring of the progression of certain diseases and the evaluation of the efficacy of …
Caspase-3-Triggered Intracellular Gadolinium Nanoparticle Formation for T1-Weighted Magnetic Resonance Imaging of Apoptosis In Vivo
HD Xu, X Cheng, X Sun, P Chen, W Zhan, X Liu… - Nano Letters, 2023 - ACS Publications
Apoptosis, with a hallmark of upregulated protease Caspase-3, has been frequently imaged
with various probes to reveal the therapeutic efficiencies of different drugs. However …
with various probes to reveal the therapeutic efficiencies of different drugs. However …
Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity
Y Wang, J Weng, X Wen, Y Hu, D Ye - Biomaterials Science, 2021 - pubs.rsc.org
Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has
been promising for the construction of molecular probes for in vivo imaging. In the past few …
been promising for the construction of molecular probes for in vivo imaging. In the past few …
[HTML][HTML] Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis alleviates excess molybdenum-induced apoptosis in duck renal tubular epithelial cells
S Pi, G Nie, Z Wei, F Yang, C Wang, C Xing… - Ecotoxicology and …, 2021 - Elsevier
Abstract Objective Excess molybdenum (Mo) is harmful to the body, and the kidney is the
vital target organ for Mo exposure. This study focused on the impacts of excess Mo on …
vital target organ for Mo exposure. This study focused on the impacts of excess Mo on …
[HTML][HTML] Rational design of caspase-responsive smart molecular probe for positron emission tomography imaging of drug-induced apoptosis
L Qiu, W Wang, K Li, Y Peng, G Lv, Q Liu, F Gao… - Theranostics, 2019 - ncbi.nlm.nih.gov
Purpose: Positron emission tomography (PET) imaging of apoptosis is very important for
early evaluation of tumor therapeutic efficacy. A stimuli-responsive probe based on the …
early evaluation of tumor therapeutic efficacy. A stimuli-responsive probe based on the …
[HTML][HTML] Overexpressed DEPDC1B contributes to the progression of hepatocellular carcinoma by CDK1
XW Dang, Q Pan, ZH Lin, HH Wang, LH Li, L Li… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Hepatocellular carcinoma (HCC) is the main type of primary liver cancer and
shows a heavy burden worldwide. Its recurrence and mortality rate are still uncontrolled by …
shows a heavy burden worldwide. Its recurrence and mortality rate are still uncontrolled by …
Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers
Controlling the access of proteases to cleavable peptides placed at specific locations within
macromolecular architectures represents a powerful strategy for biologically responsive …
macromolecular architectures represents a powerful strategy for biologically responsive …
[HTML][HTML] Apoptosis imaging in oncology by means of positron emission tomography: a review
C Van de Wiele, S Ustmert, B De Spiegeleer… - International Journal of …, 2021 - mdpi.com
To date, a wide variety of potential PET-apoptosis imaging radiopharmaceuticals targeting
apoptosis-induced cell membrane asymmetry and acidification, as well as caspase 3 …
apoptosis-induced cell membrane asymmetry and acidification, as well as caspase 3 …
Detection of Active Caspase‐3 in Mouse Models of Stroke and Alzheimer's Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [68Ga]Ga …
VG Ostapchenko, J Snir, M Suchy, J Fan… - Contrast media & …, 2019 - Wiley Online Library
Apoptosis is a feature of stroke and Alzheimer's disease (AD), yet there is no accepted
method to detect or follow apoptosis in the brain in vivo. We developed a bifunctional tracer …
method to detect or follow apoptosis in the brain in vivo. We developed a bifunctional tracer …