Alzheimer's disease (AD) is the most common form of dementia present in older adults; its
etiology involves genetic and environmental factors. In recent years, epidemiological studies …

In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …

Drug-induced gingival overgrowth is a tissue-specific condition and is estimated to affect
approximately one million North Americans. Lesions occur principally as side-effects from …

Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins,
lipids and damaged organelles to the lysosomes for degradation and elimination. The …

A major goal of contemporary epilepsy research is the identification of therapies to prevent
the development of recurrent seizures in individuals at risk, including those with brain …

The novel antiepileptic drug lacosamide (LCM; SPM927, Vimpat®) has been heralded as
having a dual-mode of action through interactions with both the voltage-gated sodium …

In view of the clinical need for new antiseizure drugs (ASDs) with novel modes of action, we
used a zebrafish seizure model to screen the anticonvulsant activity of medicinal plants used …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that lacks a disease-
modifying therapy. Leucine-rich repeat kinase 2 (LRRK2) was implicated as the most …

Glycogen synthase kinase 3beta (GSK-3β) is an enzyme with a variety of cellular functions
in addition to the regulation of glycogen metabolism. In the central nervous system, different …

Abstract Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the
brain and involved in vital molecular pathways such as cell survival and synaptic …