Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …

Objective Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear
which individuals develop it. The authors examined the contribution of genetic factors …

Genome-wide association studies (GWAS) based on high throughput SNP genotyping
technologies open a broad avenue for exploring genes associated with milk production traits …

In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits,
has become a widely researched field in human genetics. With the increasing availability of …

Joint association analysis of multiple traits in a genome-wide association study (GWAS), ie.
a multivariate GWAS, offers several advantages over analyzing each trait in a separate …

Endophenotypes are measurable biomarkers that are correlated with an illness, at least in
part, because of shared underlying genetic influences. Endophenotypes may improve our …

Identification of genetic variants affecting splicing in RNA sequencing population studies is
still in its infancy. Splicing phenotype is more complex than gene expression and ought to be …

Statistics is an integral part of research in ophthalmology. The application of appropriate
statistical strategies allows clinicians to realize the full potential in analyzing data from …

Multivariate phenotypes are frequently encountered in genetic association studies. The
purpose of analyzing multivariate phenotypes usually includes discovery of novel genetic …