The article explores the principal mechanisms of bone loss in periodontitis. The principal
feature of bone loss in this disease is enhanced osteoclast activity without a corresponding …

Defensins are antimicrobial peptides that exhibit direct microbicidal activity as well as
mediator‐like functions by, for example, activating immature dendritic cells. This review …

We have investigated the specific contribution of protease-activated receptor-2 (PAR2) to
host defense during Porphyromonas gingivalis infection. Culture supernatants from P …

The functional significance of protease-activated receptors (PARs) in endothelial cells is
largely undefined, and the intracellular consequences of their activation are poorly …

We aimed to investigate serum and gingival crevicular fluid levels of myeloperoxidase,
interleukin-17, and interleukin-23 before and after nonsurgical periodontal therapy in …

Aim To evaluate the sequential and differential expression of a variety of antimicrobial
peptides (AMP s) during the development of an experimentally induced gingivitis in humans …

The oral pathogen Porphyromonas gingivalis secretes proteases such as Arg-gingipain B
(RgpB) that activate protease-activated receptors (PARs). Human beta-defensins (hBDs) …

Protease activated receptors (PARs) are a category of G-protein coupled receptors (GPCRs)
implicated in the progression of a wide range of diseases, including thrombosis …

No evidence for the role of protease-activated receptor-2 (PAR2) in human periodontal
disease has been demonstrated so far. Thus, we sought to investigate the expression of …

The dentogingival junction is of crucial importance in periodontal host defense both
structurally and functionally. Oral bacteria exert a constant challenge to the host cells and …