Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …

Advancements in data acquisition and computational methods are generating a large
amount of heterogeneous biomedical data from diagnostic domains such as clinical …

Neoantigen‐directed therapy lacks preclinical models recapitulating neoantigen
characteristics of original tumors. It is urgent to develop a platform to assess T cell response …

In this paper, we present a toolset and related resources for rapid identification of viruses
and microorganisms from short-read or long-read sequencing data. We present fastv as an …

Background Identification of driver mutations and development of targeted therapies has
considerably improved outcomes for lung cancer patients. However, significant limitations …

Contaminations frequently occur in bacterial cultures, which significantly affect the
reproducibility and reliability of the results from whole-genome sequencing (WGS) …

Cardiovascular diseases are the number one cause of morbidity and mortality worldwide,
but the underlying molecular mechanisms remain not well understood. Cardiomyopathies …

Cancer genome sequencing has led to important discoveries such as the identification of
cancer genes. However, challenges remain in the analysis of cancer genome sequencing …

Epidemiological studies investigating transmission chains of tuberculosis are undertaken
worldwide to tackle its spread. CRISPR locus diversity, called spoligotyping, is a widely used …

Abstract Analysis of circulating cell-free DNA (cfDNA) has opened new opportunities for
characterizing tumour mutational landscapes with many applications in genomic-driven …