The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …

Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review

X Li, Y Song - European Journal of Medicinal Chemistry, 2023 - Elsevier
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

[HTML][HTML] Molecular docking, validation, dynamics simulations, and pharmacokinetic prediction of natural compounds against the SARS-CoV-2 main-protease

C Shivanika, D Kumar, V Ragunathan… - … structure & dynamics, 2020 - ncbi.nlm.nih.gov
The study aims to evaluate the potency of two hundred natural antiviral phytocompounds
against the active site of the Severe Acquired Respiratory Syndrome-Coronavirus− 2 (SARS …

The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

J Lung, YS Lin, YH Yang, YL Chou… - Journal of medical …, 2020 - Wiley Online Library
An outbreak of coronavirus disease 2019 (COVID‐19) occurred in Wuhan and it has rapidly
spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase …

Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies

M Boozari, H Hosseinzadeh - Phytotherapy Research, 2021 - Wiley Online Library
Recently, the novel life‐threatening coronavirus infection (COVID‐19) was reported at the
end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective …

Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities

R Cannalire, C Cerchia, AR Beccari… - Journal of medicinal …, 2020 - ACS Publications
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …

Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics

AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …

Natural products and their derivatives against coronavirus: A review of the non‐clinical and pre‐clinical data

MT Islam, C Sarkar, DM El‐Kersh… - Phytotherapy …, 2020 - Wiley Online Library
Several corona viral infections have created serious threats in the last couple of decades
claiming the death of thousands of human beings. Recently, corona viral epidemic raised …

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

YF Huang, C Bai, F He, Y Xie, H Zhou - Pharmacological research, 2020 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19) has been declared as a global
pandemic, but specific medicines and vaccines are still being developed. In China …

[HTML][HTML] Artificial intelligence approach fighting COVID-19 with repurposing drugs

YY Ke, TT Peng, TK Yeh, WZ Huang, SE Chang… - Biomedical journal, 2020 - Elsevier
Background The ongoing COVID-19 pandemic has caused more than 193,825 deaths
during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic …