The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
[HTML][HTML] Molecular docking, validation, dynamics simulations, and pharmacokinetic prediction of natural compounds against the SARS-CoV-2 main-protease
C Shivanika, D Kumar, V Ragunathan… - … structure & dynamics, 2020 - ncbi.nlm.nih.gov
The study aims to evaluate the potency of two hundred natural antiviral phytocompounds
against the active site of the Severe Acquired Respiratory Syndrome-Coronavirus− 2 (SARS …
against the active site of the Severe Acquired Respiratory Syndrome-Coronavirus− 2 (SARS …
The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase
An outbreak of coronavirus disease 2019 (COVID‐19) occurred in Wuhan and it has rapidly
spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase …
spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase …
Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies
M Boozari, H Hosseinzadeh - Phytotherapy Research, 2021 - Wiley Online Library
Recently, the novel life‐threatening coronavirus infection (COVID‐19) was reported at the
end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective …
end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective …
Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …
Natural products and their derivatives against coronavirus: A review of the non‐clinical and pre‐clinical data
MT Islam, C Sarkar, DM El‐Kersh… - Phytotherapy …, 2020 - Wiley Online Library
Several corona viral infections have created serious threats in the last couple of decades
claiming the death of thousands of human beings. Recently, corona viral epidemic raised …
claiming the death of thousands of human beings. Recently, corona viral epidemic raised …
Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)
YF Huang, C Bai, F He, Y Xie, H Zhou - Pharmacological research, 2020 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19) has been declared as a global
pandemic, but specific medicines and vaccines are still being developed. In China …
pandemic, but specific medicines and vaccines are still being developed. In China …
[HTML][HTML] Artificial intelligence approach fighting COVID-19 with repurposing drugs
YY Ke, TT Peng, TK Yeh, WZ Huang, SE Chang… - Biomedical journal, 2020 - Elsevier
Background The ongoing COVID-19 pandemic has caused more than 193,825 deaths
during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic …
during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic …