International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Hydrogen sulfide and cell signaling

L Li, P Rose, PK Moore - Annual review of pharmacology and …, 2011 - annualreviews.org
Hydrogen sulfide (H2S) is a gaseous mediator synthesized from cysteine by cystathionine γ
lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments using …

Regulation of autophagy of the heart in ischemia and reperfusion

SV Popov, AV Mukhomedzyanov, NS Voronkov… - Apoptosis, 2023 - Springer
Abstract Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux.
Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR …

Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis

DJ Polhemus, K Kondo, S Bhushan, SC Bir… - Circulation: Heart …, 2013 - Am Heart Assoc
Background—Hydrogen sulfide (H2S) has been shown to induce angiogenesis in in vitro
models and to promote vessel growth in the setting of hindlimb ischemia. The goal of the …

Hydrogen sulfide and autophagy: a double edged sword

D Wu, H Wang, T Teng, S Duan, A Ji, Y Li - Pharmacological research, 2018 - Elsevier
Hydrogen sulfide (H 2 S) has been considered the third gaseous signaling molecule that
plays important roles in a wide range of physiological and pathological conditions. However …

Autophagy as a therapeutic target for ischaemia/reperfusion injury? Concepts, controversies, and challenges

K Przyklenk, Y Dong, VV Undyala… - Cardiovascular …, 2012 - academic.oup.com
Autophagy is the tightly orchestrated cellular 'housekeeping'process responsible for the
degradation and disposal of damaged and dysfunctional organelles and protein aggregates …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

K Módis, EM Bos, E Calzia, H Van Goor… - British journal of …, 2014 - Wiley Online Library
Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen
sulfide (H2S), including, at lower concentrations, a stimulatory effect as an electron donor …

Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential

M Lavu, S Bhushan, DJ Lefer - Clinical science, 2011 - portlandpress.com
H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a
ubiquitously present and physiologically relevant signalling molecule. Knowledge of the …

Cardioprotective effects of hydrogen sulfide

G Szabó, G Veres, T Radovits, D Gerő, K Módis… - Nitric Oxide, 2011 - Elsevier
The gaseous mediator hydrogen sulfide (H2S) is synthesized mainly by cystathionine γ-
lyase in the heart and plays a role in the regulation of cardiovascular homeostasis. Here we …

Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury

Y Dong, VV Undyala, RA Gottlieb… - Journal of …, 2010 - journals.sagepub.com
Autophagy is the endogenous, tightly regulated cellular" housekeeping" process
responsible for the degradation of damaged and dysfunctional cellular organelles and …