Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

Serpins are a superfamily of proteins, whose membership is based on the presence of a
single common core domain consisting of three β-sheets and 8-9 R-helices, and with a set of …

Heparin is a major anticoagulant with activity mediated primarily through its interaction with
antithrombin (AT). Heparan sulfate (HS), structurally related to heparin, binds a wide range …

Serpin family protein proteinase inhibitors regulate the activity of serine and cysteine
proteinases by a novel conformational trapping mechanism that may itself be regulated by …

The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by
members of the serpin family, which use a unique β-sheet expansion mechanism to trap and …

Clinically used anticoagulants are inhibitors of enzymes involved in the coagulation
pathway, primarily thrombin and factor Xa. These agents can be either direct or indirect …

Serpins are the predominant protease inhibitors in the higher organisms and are
responsible, in humans, for the control of many highly regulated processes including blood …

Globally, the incidence of thromboembolic diseases has increased in recent years,
accompanied by an increase in patient mortality. Currently, several targeting delivery …

One of the barriers to understanding structure–property relations for glycosaminoglycans
has been the lack of constructive interplay between the principles and methodologies of the …

We describe a combinatorial virtual screening approach for predicting high specificity
heparin/heparan sulfate sequences using the well-studied antithrombin− heparin interaction …