Major depressive disorder

W Marx, BWJH Penninx, M Solmi… - Nature Reviews …, 2023 - nature.com
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus

JJ Joseph, SH Golden - Annals of the New York Academy of …, 2017 - Wiley Online Library
Controversy exists over the role of stress and depression in the pathophysiology of type 2
diabetes mellitus. Depression has been shown to increase the risk for progressive insulin …

The short-term impact of unconditional cash transfers to the poor: experimental evidence from Kenya

J Haushofer, J Shapiro - The Quarterly Journal of Economics, 2016 - academic.oup.com
We use a randomized controlled trial to study the response of poor households in rural
Kenya to unconditional cash transfers from the NGO GiveDirectly. The transfers differ from …

[HTML][HTML] Salivary biomarkers of stress, anxiety and depression

S Chojnowska, I Ptaszyńska-Sarosiek, A Kępka… - Journal of clinical …, 2021 - mdpi.com
Stress, anxiety and depressive disorders are often characterized by the activation of the
stress axis, which results in similar symptoms at some point in these disorders. These …

A unified model of depression: Integrating clinical, cognitive, biological, and evolutionary perspectives

AT Beck, K Bredemeier - Clinical Psychological Science, 2016 - journals.sagepub.com
We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …

Depression and cardiovascular disease: epidemiological evidence on their linking mechanisms

BWJH Penninx - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Depression's burden of disease goes beyond functioning and quality of life and extends to
somatic health. Results from longitudinal cohort studies converge in illustrating that major …

[HTML][HTML] Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms

E Iob, C Kirschbaum, A Steptoe - Molecular psychiatry, 2020 - nature.com
Abstract Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity and inflammation are
thought to be prominent in the aetiology of depression. Although meta-analyses have …

[HTML][HTML] Cortisol and major depressive disorder—translating findings from humans to animal models and back

LS Nandam, M Brazel, M Zhou, DJ Jhaveri - Frontiers in psychiatry, 2020 - frontiersin.org
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …

[HTML][HTML] Cortisol and development of depression in adolescence and young adulthood–a systematic review and meta-analysis

Z Zajkowska, N Gullett, A Walsh, V Zonca… - …, 2022 - Elsevier
Introduction Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the development of major depressive disorder (MDD) in adulthood. Less work …

[HTML][HTML] Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile

BWJH Penninx, Y Milaneschi, F Lamers, N Vogelzangs - BMC medicine, 2013 - Springer
Depression is the most common psychiatric disorder worldwide. The burden of disease for
depression goes beyond functioning and quality of life and extends to somatic health …