A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

The gut mucosa of human is covered by mucus, functioning as a crucial defense line for the
intestine against external stimuli and pathogens. Mucin2 (MUC2) is a subtype of secretory …

The gut microbiota plays a key role in host health and disease, particularly through their
interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic …

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the
gastrointestinal tract. Though the pathogenesis of IBD remains unclear, diet is increasingly …

Globally, breast cancer is the most frequent type of cancer in women, and most breast
cancer-associated deaths are due to metastasis and recurrence of the disease. Dietary …

Fatty acid metabolism contributes to energy supply and plays an important role in regulating
immunity. Free fatty acids (FFAs) bind to free fatty acid receptors (FFARs) on the cell surface …

Abstract Purpose Adherence to the Mediterranean diet is associated with beneficial health
effects, including gastrointestinal disorders. Preclinical studies suggest that omega-3 …

In the present study, spiro compounds are shown to have distinctive characteristics because
of their interesting conformations and their structural impacts on biological systems. A new …

Disruption of blood glucose utilization may lead to diabetes mellitus, which has complex
genetic and environmental aspects, and free fatty acid receptors (FFARs) may bridge the …

Inflammatory bowel disease, whose major forms are Crohn's disease and ulcerative colitis,
is characterized by chronic inflammation of the gut due to the loss of tolerance toward …