[HTML][HTML] Recent advances in malaria drug discovery

MA Biamonte, J Wanner, KG Le Roch - Bioorganic & medicinal chemistry …, 2013 - Elsevier
This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

Antimalarial peroxides: advances in drug discovery and design

RD Slack, AM Jacobine, GH Posner - MedChemComm, 2012 - pubs.rsc.org
Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …

Malaria and artemisinin derivatives: an updated review

M Tayyab Ansari, Z Saeed Saify… - Mini reviews in …, 2013 - ingentaconnect.com
Malaria is the world's most prevalent disease that affects 515-600 million people each year
and about 40% of the world's population live at risk for this infection. The prevalence of …

[图书][B] Treatment and prevention of malaria: antimalarial drug chemistry, action and use

HM Staines, S Krishna - 2012 - books.google.com
Malaria has defeated previous efforts at eradication and remains a massive global public
health problem despite being readily preventable and treatable. It is a devastating disease …

Exploration of macroporous polymeric sponges as drug carriers

G Duan, AR Bagheri, S Jiang, J Golenser… - …, 2017 - ACS Publications
Achieving high drug loading capacity and controlling drug delivery are two main challenges
related to drug carriers. In this study, polymeric macroporous sponges with very high pore …

Artemisinin‐derived antimalarial endoperoxides from bench‐side to bed‐side: chronological advancements and future challenges

MK Tiwari, S Chaudhary - Medicinal Research Reviews, 2020 - Wiley Online Library
Abstract According to WHO World Malaria Report (2018), nearly 219 million new cases of
malaria occurred and a total no. of 435 000 people died in 2017 due to this infectious …

Predicting Optimal Antimalarial Drug Combinations from a standardized Plasmodium falciparum humanized mouse model

C Demarta-Gatsi, N Andenmatten… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The development of new combinations of antimalarial drugs is urgently needed to prevent
the spread of parasites resistant to drugs in clinical use and contribute to the control and …

Field Surveys and Conservation Status of the Panamanian Owl Monkey (Aotus zonalis)

PG Méndez-Carvajal, PA González-Hernández… - Owl Monkeys: Biology …, 2023 - Springer
Abstract The Panamanian owl monkey (Aotus zonalis) is found from northern Coclé to
Darién provinces in Panama, south through the Pacific lowlands of the Chocó …

Antimalarial compounds in Phase II clinical development

J Held, S Jeyaraj, A Kreidenweiss - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Malaria is a major health problem in endemic countries and chemotherapy
remains the most important tool in combating it. Treatment options are limited and …

The human malaria-Aotus monkey model: a historical perspective in antimalarial chemotherapy research at the Gorgas Memorial Laboratory-Panama

N Obaldía III - Antimicrobial Agents and Chemotherapy, 2024 - Am Soc Microbiol
The human malaria-Aotus monkey model has served the malaria research community since
its inception in 1966 at the Gorgas Memorial Laboratory (GML) in Panama. Spanning over …