Single‐center pediatric experience with venetoclax and azacitidine as treatment for myelodysplastic syndrome and acute myeloid leukemia
AC Winters, KW Maloney, AL Treece… - Pediatric Blood & …, 2020 - Wiley Online Library
Background The BCL‐2 inhibitor venetoclax (ven) has revolutionized the treatment of acute
myeloid leukemia (AML) in elderly adults, leading to its recent FDA approval for this …
myeloid leukemia (AML) in elderly adults, leading to its recent FDA approval for this …
Treatment failure in acute myeloid leukemia: focus on the role of extracellular vesicles
Acute myeloblastic leukemia (AML) is one of the most common types of blood malignancies
that results in an AML-associated high mortality rate each year. Several causes have been …
that results in an AML-associated high mortality rate each year. Several causes have been …
Exosomes secreted by apoptosis-resistant acute myeloid leukemia (AML) blasts harbor regulatory network proteins potentially involved in antagonism of apoptosis
A Wojtuszkiewicz, GJ Schuurhuis, FL Kessler… - Molecular & Cellular …, 2016 - ASBMB
Expression of apoptosis-regulating proteins (B-cell CLL/lymphoma 2-BCL-2, Myeloid Cell
Leukemia 1-MCL-1, BCL-2 like 1-BCL-X and BCL-2-associated X protein-BAX) in acute …
Leukemia 1-MCL-1, BCL-2 like 1-BCL-X and BCL-2-associated X protein-BAX) in acute …
Utilizing exosomes as sparking clinical biomarkers and therapeutic response in acute myeloid leukemia
W Wang, X Wu, J Zheng, R Yin, Y Li, X Wu… - Frontiers in …, 2024 - frontiersin.org
Acute myeloid leukemia (AML) is a malignant clonal tumor originating from immature
myeloid hematopoietic cells in the bone marrow with rapid progression and poor prognosis …
myeloid hematopoietic cells in the bone marrow with rapid progression and poor prognosis …
EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells
C Wang, K Husain, A Zhang, BA Centeno… - The Journal of nutritional …, 2015 - Elsevier
The anticancer activity of δ-tocotrienol, a bioactive vitamin E present in whole grain cereals,
annatto beans and palm fruit, is strongly dependent on its effect on the induction of …
annatto beans and palm fruit, is strongly dependent on its effect on the induction of …
[HTML][HTML] Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways
X Jin, YI Shi - Experimental and therapeutic medicine, 2016 - spandidos-publications.com
In the present study, the MGC803 gastric cancer cell line was used as an experimental
model to evaluate the potential role of isobavachalcone (IBC) in cell apoptosis, migration …
model to evaluate the potential role of isobavachalcone (IBC) in cell apoptosis, migration …
[HTML][HTML] EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma
EGR1, one of the immediate-early response genes, can function as a tumor suppressor
gene or as an oncogene in cancer. The function of EGR1 has not been fully characterized in …
gene or as an oncogene in cancer. The function of EGR1 has not been fully characterized in …
Proteomic characterization of spontaneous stress-induced in vitro apoptosis of human acute myeloid leukemia cells; focus on patient heterogeneity and endoplasmic …
E Aasebø, AK Brenner, M Hernandez-Valladares… - Hemato, 2021 - mdpi.com
In vitro culture is widely used for characterization of primary human acute myeloid leukemia
(AML) cells, but even when using optimized handling and culture conditions the AML cells …
(AML) cells, but even when using optimized handling and culture conditions the AML cells …
FLT3-ITD mutation in relation to FLT3 expression in pediatric AML: a prospective study from India
SK Sharawat, R Bakhshi, S Vishnubhatla… - Pediatric Hematology …, 2014 - Taylor & Francis
There is lack of data with regard to FLT3 expression in FLT3-ITD positive pediatric AML
patients. Further, FLT3-ITD has not been systematically analyzed for outcome from Indian …
patients. Further, FLT3-ITD has not been systematically analyzed for outcome from Indian …
High receptor tyrosine kinase (FLT3, KIT) transcript versus anti-apoptotic (BCL2) transcript ratio independently predicts inferior outcome in pediatric acute myeloid …
SK Sharawat, R Bakhshi, S Vishnubhatla… - Blood Cells, Molecules …, 2015 - Elsevier
Objective In acute myeloid leukemia (AML), simultaneous expression of proliferative (FLT3,
KIT) and anti-apoptotic genes (BCL2) is unknown. The aim of the study was to prospectively …
KIT) and anti-apoptotic genes (BCL2) is unknown. The aim of the study was to prospectively …