Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

The nuclear pore complex is the sole gateway connecting the nucleoplasm and cytoplasm.
In humans, the nuclear pore complex is one of the largest multiprotein assemblies in the cell …

Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells,
enabling viral RNA replication and counteracting host antiviral responses. Here, we …

Mapping host-pathogen interactions has proven instrumental for understanding how viruses
manipulate host machinery and how numerous cellular processes are regulated. DNA …

While knowledge of protein-protein interactions (PPIs) is critical for understanding virus-host
relationships, limitations on the scalability of high-throughput methods have hampered their …

Hepatitis C virus (HCV) is a leading cause of liver disease, but insight into virus-host
interactions remains limited. We systematically used affinity purification/mass spectrometry …

Despite the introduction of effective treatments for hepatitis C in clinics, issues remain
regarding the liver disease induced by chronic hepatitis C virus (HCV) infection. HCV is …

The current therapeutic arsenal against viral infections remains limited, with often poor
efficacy and incomplete coverage, and appears inadequate to face the emergence of drug …

The integration of proteomic methods to virology has facilitated a significant breadth of
biological insight into mechanisms of virus replication, antiviral host responses and viral …

Highlights•Bacterial pathogens rewire host proteomes to enable their replication and
spread.•Identifying host-pathogen protein interactions elucidates pathogenic …