The spleen is crucial in regulating immune homoeostasis through its ability to link innate and
adaptive immunity and in protecting against infections. The impairment of splenic function is …

Reports of illness resembling meningococcal disease date back to the 16th century. The
description reported by Vieusseux in 1805 is generally thought to be the first definitive …

A major diagnostic intervention in the consideration of many patients suspected to have
primary immunodeficiency diseases (PIDDs) is the application and interpretation of …

The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to
protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of …

Preclinical and human vaccine studies indicate that, although neonatal immunisation does
not generally lead to rapid and strong antibody responses, it may result in an efficient …

A standardized serum bactericidal assay (SBA) is required to evaluate the functional activity
of antibody produced in response to Neisseria meningitidis serogroup A and C vaccines. We …

This review covers the history of meningococcal meningitis in Africa since epidemics of the
infection were first described around 100 years ago. It is possible that an epidemic strain of …

The antibody data supporting the use of meningococcal serogroup C conjugate (MCC)
vaccines in the United Kingdom were generated by serum bactericidal assay (SBA) using …

Streptococcus pneumoniae is a major cause of morbidity and mortality in children less than
5 years of age. Prevention of pneumococcal disease and death in children in the developing …

Neisseria meningitidis is the leading cause of bacterial meningitis in the United States and
worldwide. A serogroup A/C/W-135/Y polysaccharide meningococcal vaccine has been …