Radiochemistry: a hot field with opportunities for cool chemistry

GD Bowden, PJH Scott, E Boros - ACS Central Science, 2023 - ACS Publications
Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic
radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to …

Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer

JA Mattocks, JJ Jung, CY Lin, Z Dong, NH Yennawar… - Nature, 2023 - nature.com
Technologically critical rare-earth elements are notoriously difficult to separate, owing to
their subtle differences in ionic radius and coordination number,–. The natural lanthanide …

Recent advances in the chemistry of hydrometallurgical methods

GJP Deblonde, A Chagnes, G Cote - Separation & Purification …, 2023 - Taylor & Francis
Producing pure substances has been the obsession of scientists for centuries and has
defined chemistry as we know it. Nowadays, most of our economy still relies on the chemist …

A genetically encoded fluorescent sensor for manganese (II), engineered from lanmodulin

J Park, MB Cleary, D Li, JA Mattocks… - Proceedings of the …, 2022 - National Acad Sciences
The design of selective metal-binding sites is a challenge in both small-molecule and
macromolecular chemistry. Selective recognition of manganese (II)—the first-row transition …

Polyoxometalates as ligands to synthesize, isolate and characterize compounds of rare isotopes on the microgram scale

I Colliard, JRI Lee, CA Colla, HE Mason, AM Sawvel… - Nature Chemistry, 2022 - nature.com
The synthesis and study of radioactive compounds are both inherently limited by their
toxicity, cost and isotope scarcity. Traditional methods using small inorganic or organic …

Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions

JA Mattocks, JA Cotruvo, GJP Deblonde - Chemical Science, 2022 - pubs.rsc.org
Developing chelators that combine high affinity and selectivity for lanthanides and/or
actinides is paramount for numerous industries, including rare earths mining, nuclear waste …

Lanpepsy is a novel lanthanide-binding protein involved in the lanthanide response of the obligate methylotroph Methylobacillus flagellatus

JL Hemmann, P Keller, L Hemmerle… - Journal of Biological …, 2023 - ASBMB
Lanthanides were recently discovered as metals required in the active site of certain
methanol dehydrogenases. Since then, the characterization of the lanthanome, that is …

The elements of life: A biocentric tour of the periodic table

KA Remick, JD Helmann - Advances in microbial physiology, 2023 - Elsevier
Living systems are built from a small subset of the atomic elements, including the bulk
macronutrients (C, H, N, O, P, S) and ions (Mg, K, Na, Ca) together with a small but variable …

Americium preferred: lanmodulin, a natural lanthanide-binding protein favors an actinide over lanthanides

H Singer, B Drobot, C Zeymer, R Steudtner… - Chemical …, 2021 - pubs.rsc.org
The separation and recycling of lanthanides is an active area of research with a growing
demand that calls for more environmentally friendly lanthanide sources. Likewise, the …

Lanmodulin peptides–unravelling the binding of the EF-Hand loop sequences stripped from the structural corset

SM Gutenthaler, S Tsushima, R Steudtner… - Inorganic Chemistry …, 2022 - pubs.rsc.org
Lanmodulin (LanM), a naturally lanthanide (Ln)-binding protein with a remarkable selectivity
for Lns over Ca (II) and affinities in the picomolar range, is an attractive target to address …