Therapeutic strategies targeting connexins

DW Laird, PD Lampe - Nature reviews Drug discovery, 2018 - nature.com
The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Gap junctions

DA Goodenough, DL Paul - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …

Plasma membrane channels formed by connexins: their regulation and functions

JC Sáez, VM Berthoud, MC Branes… - Physiological …, 2003 - journals.physiology.org
Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

Life cycle of connexins in health and disease

DW Laird - Biochemical Journal, 2006 - portlandpress.com
Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes

MS Nielsen, CJM van Opbergen… - Physiological …, 2023 - journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

[HTML][HTML] The connexin 43 C-terminus: A tail of many tales

E Leithe, M Mesnil, T Aasen - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Connexins in the heart: regulation, function and involvement in cardiac disease

A Rodríguez-Sinovas, JA Sánchez… - International journal of …, 2021 - mdpi.com
Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Gap junctions: structure and function

WH Evans, PEM Martin - Molecular membrane biology, 2002 - Taylor & Francis
Gap junctions are plasma membrane spatial microdomains constructed of assemblies of
channel proteins called connexins in vertebrates and innexins in invertebrates. The …

Connexin43 phosphorylation: structural changes and biological effects

JL Solan, PD Lampe - Biochemical Journal, 2009 - portlandpress.com
Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical
roles in embryonic development, co-ordinated contraction of excitable cells, tissue …

Gap junction adhesion is necessary for radial migration in the neocortex

LAB Elias, DD Wang, AR Kriegstein - Nature, 2007 - nature.com
Radial glia, the neuronal stem cells of the embryonic cerebral cortex, reside deep within the
developing brain and extend radial fibres to the pial surface, along which embryonic …