The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of
inflammatory and immune cells. Tumor‐associated chronic inflammation is a hallmark of …

Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …

Lack of sensitive single-cell analysis tools has limited the characterization of metabolic
activity in cancer stem cells. By hyperspectral-stimulated Raman scattering imaging of single …

Both genomic instability and the presence of chronic inflammation are involved in
carcinogenesis and tumor progression. These alterations predispose the cancer cells to …

The cell-biological program termed the epithelial–mesenchymal transition (EMT) confers on
cancer cells mesenchymal traits and an ability to enter the cancer stem cell (CSC) state …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

The anti-tumor activities of some members of the chemokine family are often overcome by
the functions of many chemokines that are strongly and causatively linked with increased …

TWIST1 is a basic helix-loop-helix (bHLH) transcription factor which plays essential and
pivotal roles in multiple stages of embryonic development, and significantly contributes to …

Matrix mechanics regulate essential cell behaviors through mechanotransduction, and as
one of its most important elements, substrate stiffness was reported to regulate cell functions …