Development of prefrontal cortex

SM Kolk, P Rakic - Neuropsychopharmacology, 2022 - nature.com
During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …

Transient cortical circuits match spontaneous and sensory-driven activity during development

Z Molnár, HJ Luhmann, PO Kanold - Science, 2020 - science.org
BACKGROUND During early mammalian brain development, transient neurons and circuits
form the scaffold for the development of neuronal networks. In the immature cerebral cortex …

[HTML][HTML] Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

AE Trevino, F Müller, J Andersen, L Sundaram… - Cell, 2021 - cell.com
Genetic perturbations of cortical development can lead to neurodevelopmental disease,
including autism spectrum disorder (ASD). To identify genomic regions crucial to …

[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

CA Herring, RK Simmons, S Freytag, D Poppe… - Cell, 2022 - cell.com
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Prefrontal cortex development in health and disease: lessons from rodents and humans

M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

Spatially resolved epigenomic profiling of single cells in complex tissues

T Lu, CE Ang, X Zhuang - Cell, 2022 - cell.com
The recent development of spatial omics methods has enabled single-cell profiling of the
transcriptome and 3D genome organization with high spatial resolution. Expanding the …

Early diagnostics and early intervention in neurodevelopmental disorders—age-dependent challenges and opportunities

M Hadders-Algra - Journal of clinical medicine, 2021 - mdpi.com
This review discusses early diagnostics and early intervention in developmental disorders in
the light of brain development. The best instruments for early detection of cerebral palsy …

[图书][B] Volpe's Neurology of the Newborn

JJ Volpe, TE Inder, BT Darras, LS de Vries… - 2017 - books.google.com
A clear, engaging writing style, hundreds of full-color images, and new information
throughout make Volpe's Neurology of the Newborn, 6th Edition, an indispensable resource …

Advancing models of neural development with biomaterials

JG Roth, MS Huang, TL Li, VR Feig, Y Jiang… - Nature Reviews …, 2021 - nature.com
Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

LIF signaling regulates outer radial glial to interneuron fate during human cortical development

MG Andrews, C Siebert, L Wang, ML White, J Ross… - Cell stem cell, 2023 - cell.com
Radial glial (RG) development is essential for cerebral cortex growth and organization. In
humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons …