Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections

RM Fereig, MA Omar, AF Alsayeqh - Vaccines, 2022 - mdpi.com
Toxoplasmosis and neosporosis are major protozoan diseases of global distribution.
Toxoplasma gondii is the cause of toxoplasmosis, which affects almost all warm-blooded …

Microglia in neuropathology caused by protozoan parasites

K Figarella, H Wolburg, O Garaschuk… - Biological …, 2020 - Wiley Online Library
Involvement of the central nervous system (CNS) is the most severe consequence of some
parasitic infections. Protozoal infections comprise a group of diseases that together affect …

Thioredoxin reductase from Toxoplasma gondii: an essential virulence effector with antioxidant function

J Xue, W Jiang, Y Chen, F Gong, M Wang… - The FASEB …, 2017 - Wiley Online Library
Thioredoxin reductase (TR) can help pathogens resist oxidative‐burst injury from host
immune cells by maintaining a thioredoxin‐reduction state during NADPH consumption. TR …

Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice

RM Fereig, Y Kuroda, MA Terkawi, ME Mahmoud… - PLoS …, 2017 - journals.plos.org
To develop a vaccine against Toxoplasma gondii, a vaccine antigen with immune-
stimulating activity is required. In the present study, we investigated the immunogenicity and …

Neospora GRA6 possesses immune-stimulating activity and confers efficient protection against Neospora caninum infection in mice

RM Fereig, N Shimoda, HH Abdelbaky, Y Kuroda… - Veterinary …, 2019 - Elsevier
Vaccination has the potential to be the most cost-effective control measure for reducing the
economic burden of neosporosis in cattle. In this study, the immune-stimulatory effect of …

Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle

P Horcajo, D Xia, N Randle, E Collantes-Fernández… - Journal of …, 2018 - Elsevier
Neospora caninum is one of the main causes of transmissible abortion in cattle. Intraspecific
variations in virulence have been widely shown among N. caninum isolates. However, the …

Involvement of Toll-like receptor 2 in the cerebral immune response and behavioral changes caused by latent Toxoplasma infection in mice

F Ihara, S Tanaka, RM Fereig, M Nishimura… - PLoS …, 2019 - journals.plos.org
Subacute and chronic infections with the intracellular protozoan parasite Toxoplasma gondii
are associated with an increased risk of psychiatric diseases like schizophrenia. However …

Protective efficacy of recombinant Toxoplasma gondii dense granule protein 15 against toxoplasmosis in C57BL/6 mice

T Hasan, N Shimoda, S Nakamura, BA Fox, DJ Bzik… - Vaccine, 2024 - Elsevier
Toxoplasma gondii is a pervasive protozoan parasite that is responsible for significant
zoonoses. A wide array of vaccines using different effector molecules of T. gondii have been …

[PDF][PDF] Acute toxoplasmosis and antioxidant levels in the liver, kidney and brain of rats

SA Turkoglu, K Yaman, H Orallar, C Camsari… - Annals of …, 2018 - bibliotekanauki.pl
Toxoplasma gondii is a common protozoan parasite which causes toxoplasmosis
worldwide. There are limited treatment options against T. gondii infection. Once transmitted …

Evaluation of Immunodiagnostic Performances of Neospora caninum Peroxiredoxin 2 (NcPrx2), Microneme 4 (NcMIC4), and Surface Antigen 1 (NcSAG1) …

R Udonsom, P Adisakwattana, S Popruk, O Reamtong… - Animals, 2024 - mdpi.com
Simple Summary Bovine neosporosis is a widespread and economically impactful disease
affecting the dairy and meat industries globally. With no effective drug or vaccine available …