Natural product drug discovery in the artificial intelligence era

FI Saldívar-González, VD Aldas-Bulos… - Chemical …, 2022 - pubs.rsc.org
Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

The endocannabinoid system: A target for cancer treatment

C Laezza, C Pagano, G Navarra, O Pastorino… - International journal of …, 2020 - mdpi.com
In recent years, the endocannabinoid system has received great interest as a potential
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …

Pharmacological effects of cannabidiol by transient receptor potential channels

L Etemad, G Karimi, MS Alavi, A Roohbakhsh - Life Sciences, 2022 - Elsevier
Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a
promising natural compound in the treatment of diseases. Its diverse pharmacological …

Second Near‐Infrared Plasmonic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy

T Yan, M Su, Z Wang, J Zhang - Small, 2023 - Wiley Online Library
Photoacoustic imaging (PAI) and imaging‐guided photothermal therapy (PTT) in the second
near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to …

Semiconducting photothermal nanoagonist for remote-controlled specific cancer therapy

X Zhen, C Xie, Y Jiang, X Ai, B Xing, K Pu - Nano Letters, 2018 - ACS Publications
Nanomedicine have shown success in cancer therapy, but the pharmacological actions of
most nanomedicine are often nonspecific to cancer cells because of utilization of the …

Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

PSS Lima, AM Lucchese, HG Araujo-Filho… - Carbohydrate …, 2016 - Elsevier
Terpenes constitute the largest class of natural products and are important resources for the
pharmaceutical, food and cosmetics industries. However, due to their low water solubility …

Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities

S Lal, A Shekher, AS Narula, H Abrahamse… - Pharmacological …, 2021 - Elsevier
Cannabis has long been used for healing and recreation in several regions of the world.
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …

Allosteric antagonist modulation of TRPV2 by piperlongumine impairs glioblastoma progression

J Conde, RA Pumroy, C Baker, T Rodrigues… - ACS Central …, 2021 - ACS Publications
The use of computational tools to identify biological targets of natural products with
anticancer properties and unknown modes of action is gaining momentum. We employed …

TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

S Almasi, BE Kennedy, M El-Aghil, AM Sterea… - Journal of Biological …, 2018 - ASBMB
A lack of effective treatment is one of the main factors contributing to gastric cancer–related
death. Discovering effective targets and understanding their underlying anti-cancer …

Isolation of a high-affinity cannabinoid for the human CB1 receptor from a medicinal Cannabis sativa variety: Δ9-tetrahydrocannabutol, the butyl homologue of Δ9 …

P Linciano, C Citti, L Luongo, C Belardo… - Journal of natural …, 2019 - ACS Publications
The butyl homologues of Δ9-tetrahydrocannabinol, Δ9-tetrahydrocannabutol (Δ9-THCB),
and cannabidiol, cannabidibutol (CBDB), were isolated from a medicinal Cannabis sativa …