Natural product drug discovery in the artificial intelligence era
FI Saldívar-González, VD Aldas-Bulos… - Chemical …, 2022 - pubs.rsc.org
Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …
protein drug targets. Their unique characteristics and structural diversity continue to marvel …
The endocannabinoid system: A target for cancer treatment
In recent years, the endocannabinoid system has received great interest as a potential
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …
Pharmacological effects of cannabidiol by transient receptor potential channels
L Etemad, G Karimi, MS Alavi, A Roohbakhsh - Life Sciences, 2022 - Elsevier
Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a
promising natural compound in the treatment of diseases. Its diverse pharmacological …
promising natural compound in the treatment of diseases. Its diverse pharmacological …
Second Near‐Infrared Plasmonic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy
T Yan, M Su, Z Wang, J Zhang - Small, 2023 - Wiley Online Library
Photoacoustic imaging (PAI) and imaging‐guided photothermal therapy (PTT) in the second
near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to …
near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to …
Semiconducting photothermal nanoagonist for remote-controlled specific cancer therapy
Nanomedicine have shown success in cancer therapy, but the pharmacological actions of
most nanomedicine are often nonspecific to cancer cells because of utilization of the …
most nanomedicine are often nonspecific to cancer cells because of utilization of the …
Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches
PSS Lima, AM Lucchese, HG Araujo-Filho… - Carbohydrate …, 2016 - Elsevier
Terpenes constitute the largest class of natural products and are important resources for the
pharmaceutical, food and cosmetics industries. However, due to their low water solubility …
pharmaceutical, food and cosmetics industries. However, due to their low water solubility …
Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities
S Lal, A Shekher, AS Narula, H Abrahamse… - Pharmacological …, 2021 - Elsevier
Cannabis has long been used for healing and recreation in several regions of the world.
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …
Allosteric antagonist modulation of TRPV2 by piperlongumine impairs glioblastoma progression
J Conde, RA Pumroy, C Baker, T Rodrigues… - ACS Central …, 2021 - ACS Publications
The use of computational tools to identify biological targets of natural products with
anticancer properties and unknown modes of action is gaining momentum. We employed …
anticancer properties and unknown modes of action is gaining momentum. We employed …
TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway
S Almasi, BE Kennedy, M El-Aghil, AM Sterea… - Journal of Biological …, 2018 - ASBMB
A lack of effective treatment is one of the main factors contributing to gastric cancer–related
death. Discovering effective targets and understanding their underlying anti-cancer …
death. Discovering effective targets and understanding their underlying anti-cancer …
Isolation of a high-affinity cannabinoid for the human CB1 receptor from a medicinal Cannabis sativa variety: Δ9-tetrahydrocannabutol, the butyl homologue of Δ9 …
The butyl homologues of Δ9-tetrahydrocannabinol, Δ9-tetrahydrocannabutol (Δ9-THCB),
and cannabidiol, cannabidibutol (CBDB), were isolated from a medicinal Cannabis sativa …
and cannabidiol, cannabidibutol (CBDB), were isolated from a medicinal Cannabis sativa …