The unusual regenerative properties of the liver are a logical adaptation by organisms, as
the liver is the main detoxifying organ of the body and is likely to be injured by ingested …

In mammals, cyclic adenosine monophosphate (cAMP) is an intracellular second
messenger that is usually elicited by binding of hormones and neurotransmitters to G protein …

Liver regeneration stimulated by a loss of liver mass leads to hepatocyte and
nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Mice with …

Fetal liver, the major site of hematopoiesis during embryonic development, acquires
additional various metabolic functions near birth. Although liver development has been …

While insulin has long been known to modulate intracellular metabolism by altering the
activity or intracellular location of various enzymes, it is only in the past 10 years that the …

Hepatoblasts are common progenitors for hepatocytes and biliary epithelial cells, although
their nature remains largely unknown. In order to isolate and to characterize hepatoblasts …

Glycogen storage disease type I (GSD-I) is a group of autosomal recessive disorders with an
incidence of 1 in 100,000. The two major subtypes are GSD-Ia (MIM232200), caused by a …

The liver plays a central role in metabolism, protein synthesis and detoxification. It
possesses unique regenerative capacity upon injury. While many factors regulating cellular …

Determining what factors are responsible for initiating regeneration following partial
hepateetomy or toxic damage, and how the liver maintains differentiated functions while the …

After two-thirds hepatectomy, normally quiescent liver cells are stimulated to reenter the cell
cycle and proliferate to restore the original liver mass. The level of bZIP transcription factor …