[HTML][HTML] Ion channels in the heart

DC Bartos, E Grandi, CM Ripplinger - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?

PG Meregalli, AAM Wilde, HL Tan - Cardiovascular research, 2005 - academic.oup.com
After its recognition as a distinct clinical entity, Brugada syndrome is increasingly recognized
worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits …

Electrical substrate elimination in 135 consecutive patients with Brugada syndrome

C Pappone, J Brugada, G Vicedomini… - Circulation …, 2017 - Am Heart Assoc
Background—There is emerging evidence that localization and elimination of abnormal
electric activity in the epicardial right ventricular outflow tract may be beneficial in patients …

Brugada syndrome phenotype elimination by epicardial substrate ablation

J Brugada, C Pappone, A Berruezo… - Circulation …, 2015 - Am Heart Assoc
Background—Whether Brugada syndrome (BrS) depends on functional epicardial
substrates, which may be definitively eliminated by radiofrequency ablation, remains …

Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome

H Morita, KF Kusano, D Miura, S Nagase… - Circulation, 2008 - Am Heart Assoc
Background—Conduction abnormalities serve as a substrate for ventricular fibrillation (VF)
in patients with Brugada syndrome (BS). Signal-averaged electrograms can detect late …

Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study

F Sacher, V Probst, Y Iesaka, P Jacon, J Laborderie… - Circulation, 2006 - Am Heart Assoc
Background—Brugada syndrome is an arrhythmogenic disease characterized by an
increased risk of sudden cardiac death (SCD) by ventricular fibrillation. At present, an …

Atrial fibrillation in patients with Brugada syndrome: relationships of gene mutation, electrophysiology, and clinical backgrounds

KF Kusano, M Taniyama, K Nakamura, D Miura… - Journal of the American …, 2008 - jacc.org
Objectives: The goal of our work was to examine the relationships of atrial fibrillation (AF)
with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS) …

Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data

M Paul, J Gerss, E Schulze-Bahr, T Wichter… - European heart …, 2007 - academic.oup.com
Aims Brugada syndrome (BS) is an ion channelopathy with the risk of sudden cardiac death.
The role of programmed ventricular stimulation (PVS) in risk stratification has been …

Delay in right ventricular activation contributes to Brugada syndrome

R Tukkie, P Sogaard, J Vleugels, IKLM De Groot… - Circulation, 2004 - Am Heart Assoc
Background—Although Brugada syndrome revolves around reduced net depolarizing force,
the electrophysiological mechanisms of its defining features (right precordial ST-segment …

JCS/JHRS 2022 guideline on diagnosis and risk assessment of arrhythmia

B Takase, T Ikeda, W Shimizu, H Abe, T Aiba… - Circulation …, 2023 - jstage.jst.go.jp
Sinus node dysfunction may be either transient (reversible/physiological) due to the
involvement of the autonomic nervous system or pharmaceuticals, or chronic due to …