The synaptic vesicle protein Synaptophysin (Syp) has long been known to form a complex
with the Vesicle associated soluble N-ethylmaleimide sensitive fusion protein attachment …

Highlights•In situ cryo-ET provides novel mechanistic insights into neuronal biology.•Cryo-
ET enables cellular structural studies of neurodegeneration.•Recent developments allow …

Synapses maintain two forms of neurotransmitter release to support communication in the
brain. First, evoked neurotransmitter release is triggered by the invasion of an action …

Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here,
we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich …

Neurotransmitter release consists of rapid synchronous release followed by longer-lasting
asynchronous release (AR). Although the presynaptic proteins that trigger synchronous …

Various cell types release neurotransmitters, hormones and many other compounds that are
stored in secretory vesicles by exocytosis via the formation of a fusion pore traversing the …

Synaptotagmin-1 (Syt1) is a calcium sensor that regulates synaptic vesicle fusion in
synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the …

Abstract Synaptotagmin-1 (Syt-1) self-assembles into ring-like oligomers, and genetic and
biochemical evidence suggest that oligomerization is needed to clamp synaptic vesicles and …

The critical presynaptic protein Munc13 serves numerous roles in the process of docking
and priming synaptic vesicles. Here we investigate the functional significance of two distinct …

Although synapsins have long been proposed to be key regulators of synaptic vesicle (SV)
clustering, their mechanism of action has remained mysterious and somewhat controversial …