Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial
plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of …

The continued spread of drug-resistant tuberculosis is one of the most pressing and complex
challenges facing tuberculosis management worldwide. Therefore, developing a new class …

13a-(S)-3-pivaloyloxyl-6, 7-dimethoxyphenanthro (9, 10-b)-indolizidine (CAT3) is a novel
oral anti-glioma pro-drug with a potent anti-tumor effect against temozolomide-resistant …

Nature is an attractive source of therapeutic and preventive compounds, and with such
chemical diversity found in millions of species of plants, over 60% of currently used …

Medulloblastoma (MB) and glioblastoma (GBM) are the most prevalent malignant brain
tumors. The identification of novel therapeutic strategies is urgent for MB and GBM patients …

Background The increasing incidence of multidrug-resistant tuberculosis (MDR-TB)
infections has created a need for new effective drugs that also target extensively drug …

CAT3, one of the (+)-deoxytylophorinine-based phenanthroindolizidine alkaloids, is a
promising therapeutic agent for the treatment of hedgehog (Hh)-driven glioblastoma and is …

A new series of novel 1-phenanthryl-tetrahydroisoquinoline derivatives were designed,
synthesized and biologically evaluated for their PAK4 inhibitory activities and anti …

13 a-(S)-3-pivaloyloxyl-6, 7-dimethoxyphenanthro (9, 10-b)-indolizidine (CAT3) is a novel
oral anti-glioma pro-drug with a potent anti-tumor effect against temozolomide-resistant …

Neuroblastoma is the most common cancer in infants and the fourth most common cancer in
children. Our previous study showed that PF403 had a potent antitumor ability. In the present …