Toxicity prediction is a critical step in the drug discovery process that helps identify and
prioritize compounds with the greatest potential for safe and effective use in humans, while …

Across the spectrum of industrial sectors, including pharmaceuticals, chemicals, personal
care products, food additives and their associated regulatory agencies, there is a need to …

Over the last ten years, the field of dermatology has experienced significant advancements
through the utilization of artificial intelligence (AI) technologies. The adoption of such …

In silico tools and resources are now used commonly in toxicology and to support the “Next
Generation Risk Assessment”(NGRA) of cosmetics ingredients or materials. This review …

Neurotoxicology is the study of adverse effects on the structure or function of the developing
or mature adult nervous system following exposure to chemical, biological, or physical …

Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …

Hepatotoxicity is one of the most frequently observed adverse effects resulting from
exposure to a xenobiotic. For example, in pharmaceutical research and development it is …

Highlights•Preclinical safety may profit from increasing availability of pre-/clinical
data.•Success will depend on appropriate data curation, terminologies, and data platforms.• …

The kidneys, heart and lungs are vital organ systems evaluated as part of acute or chronic
toxicity assessments. New methodologies are being developed to predict these adverse …

Skin direct contact with chemical or physical substances is predisposed to allergic contact
dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the …