The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and …

Tau is a neuronal microtubule-associated protein (MAP) that is involved in the regulation of
axonal microtubule assembly. However, as a protein with intrinsically disordered regions …

Tau is a microtubule-associated protein, which is highly expressed in the central nervous
system as well as ocular neurons and stabilizes microtubule structure. It is a phospho …

Photoreceptors have high metabolic demands and age rapidly, undermining visual function.
We base our understanding mainly on ageing mice where elevated inflammation …

Accumulation of misfolded host proteins is central to neuropathogenesis of numerous
human brain diseases including prion and prion-like diseases. Neurons of retina are also …

While Alzheimer's disease (AD) is associated with inner retina thinning (retinal nerve fiber
layer and ganglion cell layer), we have observed photoreceptor outer nuclear layer (ONL) …

Photoreceptor cells undergo changes with aging. It is unknown if their microtubules are
stable or not with aging. This study examined photoreceptor cell ultrastructure from 18 …

A defining feature of catarrhine primates is uniform trichromacy—the ability to distinguish red
(long; L), green (medium; M), and blue (short; S) wavelengths of light. Although the tuning of …

The implication of the microtubule-associated protein (MAP) Tau in the ocular manifestations
of Alzheimer's disease (AD) is elusive due to the lack of relevant animal model. However …