Currently, the number of new cancer cases and deaths worldwide is increasing year on
year. In addition to the requirement for cancer prevention, the top priority is still to seek the …

Chiral phosphonium salt catalysis, traditionally classified as a type of phase transfer
catalysis, has proven to be a powerful strategy for the stereoselective preparation of diverse …

Abstract Sarpagine-Ajmaline-Koumine type monoterpenoid indole alkaloids represent a
fascinating class of natural products with polycyclic and cage-like structures, interesting …

We report here a concise, collective, and asymmetric total synthesis of sarpagine alkaloids
and biogenetically related koumine alkaloids, which structurally feature a rigid cage scaffold …

Indole‐containing compounds demonstrate an array of biological activities relevant to
numerous human diseases. The biological activities of diverse indole‐based agents are …

Sarpagine alkaloids offer signicant opportunities in drug discovery, yet the efficient total
syntheses and diverse structural modifications of these natural products remain highly …

As the growth in resistance to bacterial infection treatments poses a grave threat to global
health in the 21st century, there is a constant need to explore novel antibacterial agents that …

Biosynthetic processes often involve reorganization of one family of natural products to
another. Chemical emulation of nature's rearrangement-based structural diversification …

Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically
active compounds. Indole alkaloids have the potential to exert anticancer activity via various …

Herein we develop a new “cobalt (II)/organic oxidant” catalytic system for the selective
activation of 1°, 2°, and 3° C (sp3)–H bonds to construct C–N and C–O bonds, respectively …