Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials
A Anglemyer, HT Horvath… - Cochrane Database of …, 2014 - cochranelibrary.com
Background Researchers and organizations often use evidence from randomized controlled
trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions …
trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions …
How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature
Clinical decisions should be based on the totality of the best evidence and not the results of
individual studies. When clinicians apply the results of a systematic review or meta-analysis …
individual studies. When clinicians apply the results of a systematic review or meta-analysis …
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …
trials. However, the completeness of trial protocols is often inadequate. To help improve the …
[PDF][PDF] Guidelines for reporting meta-epidemiological methodology research
Published research should be reported to evidence users with clarity and transparency that
facilitate optimal appraisal and use of evidence and allow replication by other researchers …
facilitate optimal appraisal and use of evidence and allow replication by other researchers …
A pragmatic view on pragmatic trials
NA Patsopoulos - Dialogues in clinical neuroscience, 2011 - Taylor & Francis
Clinical trials have been the main tool used by the health sciences community to test and
evaluate interventions. Trials can fall into two broad categories: pragmatic and explanatory …
evaluate interventions. Trials can fall into two broad categories: pragmatic and explanatory …
Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis
This review is an abridged version of a Cochrane Review previously published in the
Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI …
Cochrane Database of Systematic Reviews 2010, Issue 4, Art. No.: MR000013 DOI …
Audit and feedback: effects on professional practice and healthcare outcomes
N Ivers, G Jamtvedt, S Flottorp… - Cochrane database …, 2012 - cochranelibrary.com
Background Audit and feedback is widely used as a strategy to improve professional
practice either on its own or as a component of multifaceted quality improvement …
practice either on its own or as a component of multifaceted quality improvement …
Understanding GRADE: an introduction
G Goldet, J Howick - Journal of Evidence‐Based Medicine, 2013 - Wiley Online Library
Objective Grading of recommendations, assessment, development, and evaluations
(GRADE) is arguably the most widely used method for appraising studies to be included in …
(GRADE) is arguably the most widely used method for appraising studies to be included in …
Failure of a numerical quality assessment scale to identify potential risk of bias in a systematic review: a comparison study
Background Assessing methodological quality of primary studies is an essential component
of systematic reviews. Following a systematic review which used a domain based system …
of systematic reviews. Following a systematic review which used a domain based system …
Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments
VC Henderson, J Kimmelman, D Fergusson… - PLoS …, 2013 - journals.plos.org
Background The vast majority of medical interventions introduced into clinical development
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …