TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing
centers of animal cells. Extra centrosomes are a common feature of cancer cells. To …

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle
apparatus. Centrosomes themselves duplicate once per cell cycle, in a process that is …

Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel,
docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …

TP53 is a key tumor suppressor gene with protean functions associated with preservation of
genomic balance, including regulation of cellular senescence, apoptotic pathways …