Cancer is generally characterized by acquired genomic aberrations in a broad spectrum of
types and sizes, ranging from single nucleotide variants to structural variants (SVs). At least …

Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and
is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade …

Pediatric brain tumors are the leading cause of childhood cancer-related death.
Immunotherapy is a powerful new approach for treating some refractory cancers; applying …

Within the AGC kinase superfamily, gene fusions resulting from chromosomal
rearrangements have been most frequently described for protein kinase C (PKC), with gene …

Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental
disorder with only symptomatic care available. Genome-wide association (GWA) studies can …

Malignant peripheral nerve sheath tumor (MPNST), often arising from a (plexiform)
neurofibroma, is one of the hallmark complications of neurofibromatosis type 1 (NF1) …

Background Gene fusions are important cancer drivers in pediatric cancer and their accurate
detection is essential for diagnosis and treatment. Clinical decision-making requires high …

High-grade glioma (HGG) and glioblastoma are the most common adult malignant brain
tumors. The standard treatment consists of surgical resection followed by …

The human leukocyte antigen (HLA) system is a major factor controlling cancer
immunosurveillance and response to immunotherapy, yet its status in pediatric cancers …