We review the status of protein-based molecular electronics. First, we define and discuss
fundamental concepts of electron transfer and transport in and across proteins and …

Abstract Surface Plasmon Resonance (SPR) technology has been proven to be a significant
approach for target-based drug discovery and development in the modern era. SPR unfolds …

De novo variants (DNVs) cause many genetic diseases. When DNVs are examined in the
whole coding regions of genes in next-generation sequencing analyses, pathogenic DNVs …

Caffeic acid is a plant phenolic compound possessing extensive pharmacological activities.
Here, we identified that p-coumaric acid 3-hydroxylase from Arabidopsis thaliana was …

We explore the mechanism of electron transfers mediated by cytochrome c, a soluble protein
involved in mitochondrial oxidative phosphorylation and cytochrome b 5, a microsomal …

Cytochrome P450 (CYP) enzyme kinetics often do not conform to Michaelis-Menten
assumptions, and time-dependent inactivation (TDI) of CYPs displays complexities such as …

Cytochrome P450 enzymes, which catalyze oxygenation reactions of both exogenous and
endogenous chemicals, are membrane bound proteins that require interaction with their …

The current article aims to summarize all possible spectrum of protein–protein interactions
for thromboxane A synthase (CYP5A1) and prostacyclin synthase (CYP8A1). These …

Abstract Cytochromes P450 (CYP), enzymes involved in the metabolism of endogenous and
xenobiotic substrates, provide an excellent model system to study how membrane proteins …

In recent years, a growing appreciation has developed for the importance of protein-protein
interactions to modulate the function of drug metabolizing enzymes. Accompanied with this …