Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

The onset of cardiomyopathy is a common feature in sepsis, with relevant effects on its
pathophysiology and clinical care. Septic cardiomyopathy is characterized by reduced left …

Nitric oxide (NO) is produced by enzymatic activity of neuronal (nNOS), endothelial (eNOS),
and inducible nitric oxide synthase (iNOS) and modulates a broad spectrum of physiological …

Antibody use is a critical component of cardiovascular physiology research, and antibodies
are used to monitor protein abundance (immunoblot analysis) and protein expression and …

The problem of inadequate statistical reporting is long standing and widespread in the
biomedical literature, including in cardiovascular physiology. Although guidelines for …

Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high
mortality rates. Its pathophysiology involves complex factors, including inflammatory …

Sepsis-induced myocardial injury is a well-known cause of mortality. The cholinergic anti-
inflammatory pathway (CHAIP) is a physiological mechanism by which the central nervous …

Objective Sepsis is a major cause of mortality among critically ill patients in the intensive
care unit (ICU). Alterations in serum amyloid A (SAA) and nitric oxide (NO) levels have been …

Sepsis, a leading cause of death in intensive care units, is primarily caused due to an
exaggerated immune response. The hyperactive inflammatory response mediated by …