Age‐associated alterations in bladder control affect millions of older adults, with a heavy
burden added to families both economically and in quality of life. Therapeutic options are …

Discovered some 40 years ago, the I f current has since been known as the “pacemaker”
current due to its role in the initiation and modulation of the heartbeat and of neuronal …

Volume hyposensitivity resulting from impaired sympathetic detrusor relaxation during
bladder filling contributes to detrusor underactivity (DU) associated with aging. Detrusor …

A geroscience-informed approach to the increasing prevalence of bladder control problems
in older adults requires understanding the impact of aging on dynamic mechanisms that …

Objective To assess the functional role of Hyperpolarization-activated cyclic nucleotide-
gated gated channel (HCN) subtypes in the aging bladder phenotype characterized by …

Multiple sclerosis (MS) is a chronic, progressively debilitating demyelinating disease of the
central nervous system (CNS). Nearly 80% of MS patients experience lower urinary tract …

Control of urinary continence is predicated on sensory signaling about bladder volume.
Bladder sensory nerve activity is dependent on tension, implicating autonomic control over …

Background: While symptoms related to lower urinary tract dysfunction (LUTD) are common
in individuals with Alzheimer's disease (AD), pathophysiological links between AD and …

Control of urinary continence is predicated on sensory signaling about bladder volume.
Bladder sensory nerve activity is dependent on tension, implicating autonomic control over …

Bothersome urinary symptoms plague many older adults and disproportionally affect
women. Under reporting of symptoms and general stigma/embarrassment associated with …