The p21-activated kinases (PAKs) are serine/threonine protein kinases interacting with small
GTPases-Rac and Cdc42. PAKs are found in most eukaryotes and play an evolutionarily …

The p21‐activated kinases (PAKs) are signaling nodes that play a crucial role in cellular
processes including cell motility, differentiation, survival, gene transcription, and hormone …

Endothelial cells lining the vasculature have close cell-cell associations that maintain
separation of the blood fluid compartment from surrounding tissues. Permeability is …

p21-activated protein kinase (PAK) 2 is a small GTPase-activated serine/threonine kinase
regulating various cytoskeletal functions and is cleaved by caspase-3 during apoptosis. We …

Myosin II activation is essential for stress fiber and focal adhesion formation, and is
implicated in integrin-mediated signaling events. In this study we investigated the role of …

The roles of P21-activated kinase (PAK) in the regulation of axon outgrowth downstream of
extracellular matrix (ECM) proteins are poorly understood. Here we show that PAK1–3 and …

The control of cell adhesion is an important mechanism by which Eph receptors regulate cell
sorting during development. Activation of EphA4 in Xenopus blastulae induces a reversible …

Xenopus provides a well-studied model of vertebrate gastrulation, but a central feature, the
movement of the mesoderm to the interior of the embryo, has received little attention. Here …

Fragile X-related 1 protein (FXR1P) is a member of a small family of RNA-binding proteins
that includes the Fragile X mental retardation 1 protein (FMR1P) and the Fragile X-related 2 …

The p21-activated kinase (PAK) proteins regulate many cellular events including cell cycle
progression, cell death and survival, and cytoskeleton rearrangements. We previously …