The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …

Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating
disease of the central nervous system (CNS). Although a number of histological …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Objective Conventional magnetic resonance imaging (MRI) of the multiple sclerosis spinal
cord is limited by low specificity regarding the underlying pathological processes, and new …

It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and
priming neuroinflammation. However, despite more than a century of intense research on …

Objectives In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool
for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous …

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are
critical determinants of neuroinflammatory diseases. However, the mechanisms that drive …

Disruption of the blood–brain barrier (BBB) is critical to initiation and perpetuation of disease
in multiple sclerosis (MS). We report an interaction between oligodendroglia and …