The roles of IL-1 family cytokines in the pathogenesis of systemic sclerosis

D Xu, R Mu, X Wei - Frontiers in immunology, 2019 - frontiersin.org
The IL-1 family consists of 11 cytokines, 7 ligands with agonist activity (IL-1α, IL-1β, IL-18, IL-
33, IL-36α, IL-36β, IL-36γ) and four members with antagonistic activities [IL-1 receptor …

Interleukin-1 and systemic sclerosis: getting to the heart of cardiac involvement

G De Luca, G Cavalli, C Campochiaro, C Bruni… - Frontiers in …, 2021 - frontiersin.org
Systemic sclerosis (SSc) is rare, severe connective tissue disease characterized by
endothelial and vascular damage, immune activation, and resulting in inflammation and …

Genetic factors and systemic sclerosis

G Murdaca, M Contatore, R Gulli, P Mandich… - Autoimmunity …, 2016 - Elsevier
Systemic sclerosis (SSc) is a rare connective tissue disease of unknown etiology
characterized by chronic inflammation and fibrosis of the skin, vascular abnormalities, and …

Targeting TLRs and the inflammasome in systemic sclerosis

J Henderson, S Bhattacharyya, J Varga… - Pharmacology & …, 2018 - Elsevier
Systemic sclerosis (SSc) is an idiopathic autoimmune disease characterised by
inflammation, vascular problems, cytokine dysregulation and ultimately fibrosis, which …

Cardiovascular, respiratory, and total mortality ascribed to PM10 and PM2. 5 exposure in Isfahan, Iran

A Abdolahnejad, N Jafari, A Mohammadi… - Journal of education …, 2017 - journals.lww.com
BACKGROUND: Elderly people often suffer from sleep disorders. Chamomile due to the
many health benefits such as sedation may be effective in improving sleep quality in elderly …

Association of C3953T transition in interleukin 1β gene with idiopathic male infertility in an Iranian population

T Zamani-Badi, M Karimian, A Azami-Tameh… - Human …, 2019 - Taylor & Francis
In this study we investigate the association of C3953T transition single nucleotide
polymorphism in the fifth exon of the interleukin 1β gene with idiopathic male infertility. In a …

The immunogenetics of systemic sclerosis

B Ünlü, Ü Türsen, Z Rajabi, N Jabalameli… - The Immunogenetics of …, 2022 - Springer
Systemic sclerosis (SSc) is a rare disease with a prevalence ranging from 7 to 700 cases per
million. Like with most autoimmune diseases, both environmental and genetic factors are …

Relationships between IL-1β, TNF-α genetic polymorphisms and HBV infection: A meta-analytical study

Y Wei, Z Zhao, Z Wang, K Zhang, Z Tang, C Tao - Gene, 2021 - Elsevier
Background IL-1β and TNF-α have been demonstrated as pro-inflammatory cytokines to
participate in the innate immune response and suppression of HBV infection. However, the …

Evaluation of ITGB2 (CD18) and SELL (CD62L) genes expression and methylation of ITGB2 promoter region in patients with systemic sclerosis

N Dashti, M Mahmoudi, F Gharibdoost… - Rheumatology …, 2018 - Springer
Systemic sclerosis (SSc), an autoimmune disease of connective tissue, is characterized by
inflammation, fibrosis, and vessel endothelial damage. Products of Integrin subunit beta 2 …

Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis

M Mahmoudi, F Fallahian, S Sobhani, S Ghoroghi… - Clinical …, 2017 - Springer
Genetic factors have a great role in the pathogenesis of autoimmune diseases by
cooperating with environmental stimuli. Killer immunoglobulin-like receptors (KIRs) are cell …