Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
A walk through tau therapeutic strategies
S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …
and related human tauopathies. There is a growing body of evidence indicating that …
Four distinct trajectories of tau deposition identified in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the spread of tau pathology throughout the
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …
Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …
remains unclear how these proteins interact to promote disease. Here, by combining cross …
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
JW Vogel, Y Iturria-Medina, OT Strandberg… - Nature …, 2020 - nature.com
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease
In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity …
Preclinical evidence suggests that tau spreads across connected neurons in an activity …
The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography
Advances in molecular positron emission tomography (PET) have enabled anatomic
tracking of brain pathology in longitudinal studies of normal aging and dementia, including …
tracking of brain pathology in longitudinal studies of normal aging and dementia, including …
High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies
K Tagai, M Ono, M Kubota, S Kitamura, K Takahata… - Neuron, 2021 - cell.com
A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal …
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal …
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein
accumulation leading to neuronal death in focal brain areas. Positron emission tomography …
accumulation leading to neuronal death in focal brain areas. Positron emission tomography …
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease
N Franzmeier, A Dewenter, L Frontzkowski… - Science …, 2020 - science.org
In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau
spreading pattern that does, however, not capture interindividual variability in tau deposition …
spreading pattern that does, however, not capture interindividual variability in tau deposition …