Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Y Geng, Z Wang, J Zhou, M Zhu, J Liu… - Chemical Society …, 2023 - pubs.rsc.org
Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Inflammation and resolution signaling in cardiac repair and heart failure

GV Halade, DH Lee - EBioMedicine, 2022 - thelancet.com
Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage,
pathogen, and lifestyle-associated molecular patterns are the major factors in initiating …

Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration

CN Serhan, N Chiang - Prostaglandins & other lipid mediators, 2023 - Elsevier
This review is a synopsis of the main points from the opening presentation by the authors in
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …

TRAF3/STAT6 axis regulates macrophage polarization and tumor progression

JH Shi, LN Liu, DD Song, WW Liu, C Ling… - Cell Death & …, 2023 - nature.com
Converting tumor-associated macrophages (TAMs) from the M2 to the M1 phenotype is
considered an effective strategy for cancer therapy. TRAF3 is known to regulate NF-κB …

Resolution of inflammation in oral diseases

EG Eltay, T Van Dyke - Pharmacology & therapeutics, 2023 - Elsevier
The resolution of inflammation is an essential endogenous process that protects host tissues
from an exaggerated chronic inflammatory response. Multiple interactions between host …

Obesity dysregulates the immune response to influenza infection and vaccination through metabolic and inflammatory mechanisms

SR Shaikh, NJ MacIver, MA Beck - Annual review of nutrition, 2022 - annualreviews.org
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …

Protectins PCTR1 and PD1 reduce viral load and lung inflammation during respiratory syncytial virus infection in mice

KH Walker, N Krishnamoorthy… - Frontiers in …, 2021 - frontiersin.org
Viral pneumonias are a major cause of morbidity and mortality, owing in part to dysregulated
excessive lung inflammation, and therapies to modulate host responses to viral lung injury …

Pro-resolving ligands orchestrate phagocytosis

C Decker, S Sadhu, G Fredman - Frontiers in immunology, 2021 - frontiersin.org
The resolution of inflammation is a tissue protective program that is governed by several
factors including specialized pro-resolving mediators (SPMs), proteins, gasses and …

Role of specialized pro-resolving mediators in modifying host defense and decreasing bacterial virulence

JM Thornton, K Yin - Molecules, 2021 - mdpi.com
Bacterial infection activates the innate immune system as part of the host's defense against
invading pathogens. Host response to bacterial pathogens includes leukocyte activation …