[HTML][HTML] NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Signaling via the NFκB system
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …
development, immune responses, inflammation, and cancer. The NFκB signaling system …
[HTML][HTML] Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …
related proteins that transduces signals from members of TNFR superfamily and various …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
[HTML][HTML] The unique molecular and cellular microenvironment of ovarian cancer
T Worzfeld, E Pogge von Strandmann, M Huber… - Frontiers in …, 2017 - frontiersin.org
The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for
tumor growth and progression. Cells of both the innate and adaptive immune system, in …
tumor growth and progression. Cells of both the innate and adaptive immune system, in …
[HTML][HTML] Environmental control of astrocyte pathogenic activities in CNS inflammation
MA Wheeler, M Jaronen, R Covacu, SEJ Zandee… - Cell, 2019 - cell.com
Genome-wide studies have identified genetic variants linked to neurologic diseases.
Environmental factors also play important roles, but no methods are available for their …
Environmental factors also play important roles, but no methods are available for their …
[HTML][HTML] A single NFκB system for both canonical and non-canonical signaling
VFS Shih, R Tsui, A Caldwell, A Hoffmann - Cell research, 2011 - nature.com
Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …
[HTML][HTML] IL-10 constrains sphingolipid metabolism to limit inflammation
Abstract Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell
activation and cytokine production in innate immune cell types. Loss of IL-10 signalling …
activation and cytokine production in innate immune cell types. Loss of IL-10 signalling …
Circuitry of nuclear factor κB signaling
A Hoffmann, D Baltimore - Immunological reviews, 2006 - Wiley Online Library
Over the past few years, the transcription factor nuclear factor (NF)‐κB and the proteins that
regulate it have emerged as a signaling system of pre‐eminent importance in human …
regulate it have emerged as a signaling system of pre‐eminent importance in human …
Transcriptional regulation via the NF-κB signaling module
Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …
responses and immune function, comprises a family of dimeric transcription factors that …