abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

During cancer progression, cancer cells are repeatedly exposed to metabolic stress
conditions in a resource-limited environment which they must escape. Increasing evidence …

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and major
cause of cancer death in the world. Ferroptosis is a recently identified type of regulated cell …

The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising
fibroblasts, cells of the immune system, and endothelial cells, besides various soluble …

Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …

For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …

Metabolic reprogramming is considered hallmarks of cancer. Aerobic glycolysis in tumors
cells has been well-known for almost a century, but specific factors that regulate lactate …

Atherosclerosis (AS) is a chronic disease with a complex pathology that may lead to several
cardiovascular and cerebrovascular diseases; however, further research is necessary to …

Metabolic reprogramming is a potential hallmark of tumor cells to support continuous
proliferation. Metabolic heterogeneity in breast cancer patients has been highlighted as the …

Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to
the acquisition of DNA mutations and genomic instability in cancer. How genomic instability …