The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …

We discuss mini MS systems in terms of individual components and at a systems level.
Portable systems from academic and commercial laboratories are emphasized, but meso …

This review discusses advances in the field of ambient sampling/ionization mass
spectrometry (“ambient MS” for short) with a focus on mechanistic and instrumentation …

Molecular analysis at cellular and subcellular levels, whether on selected molecules or at
the metabolomics scale, is still a challenge now. Here we propose a method based on probe …

Paper spray ionization has grown to become one of the most successful ambient ionization
methods within the past decade. Requiring little to no sample preparation and being …

Cells are the most basic structural units that play vital roles in the functioning of living
organisms. Analysis of the chemical composition and content of a single cell plays a vital …

Recent advancements in the sensitivity of chemical instrumentation have led to increased
interest in the use of microsamples for translational and biomedical research. Paper …

In this review we highlight the general change in perception in the field of ambient mass
spectrometry that it is the immediacy of sample preparation that differentiates the ambient …

The definition of ambient ionization is updated from “no sample preparation” to sample
preparation proximal and in real time with the ionization and analysis step. We differentiate …

Substrate-based electrospray ionization (ESI) techniques like paper, wooden tip, plastic tip,
and metal-needle-based spray suffer from corona discharge, high background noise, and …