The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Collagen hydrogels are among​ the most well-studied platforms for drug delivery and in situ
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …

The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that
are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …

We study a unique biomaterial developed from fungal mycelium, the vegetative part and the
root structure of fungi. Mycelium has a filamentous network structure with mechanics largely …

Collagen is the main structural and load-bearing element of various connective tissues,
where it forms the extracellular matrix that supports cells. It has long been known that …

Replicating the multi-hierarchical self-assembly of collagen has long-attracted scientists,
from both the perspective of the fundamental science of supramolecular chemistry and that …

Collagen forms fibrous networks that reinforce tissues and provide an extracellular matrix for
cells. These networks exhibit remarkable strain-stiffening properties that tailor the …

Wound dressing biomaterials are increasingly being designed to incorporate bioactive
molecules to promote healing, but the impact of matrix mechanical properties on the biology …