Kynurenines in the mammalian brain: when physiology meets pathology
R Schwarcz, JP Bruno, PJ Muchowski… - Nature Reviews …, 2012 - nature.com
The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …
degraded to several other neuroactive compounds, including kynurenic acid, 3 …
Kynurenic acid in schizophrenia: a systematic review and meta-analysis
Kynurenic acid (KYNA) is an endogenous antagonist of N-methyl-D-aspartate and α7
nicotinic acetylcholine receptors that is derived from astrocytes as part of the kynurenine …
nicotinic acetylcholine receptors that is derived from astrocytes as part of the kynurenine …
An expanding range of targets for kynurenine metabolites of tryptophan
TW Stone, N Stoy, LG Darlington - Trends in pharmacological sciences, 2013 - cell.com
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that
is not committed to protein synthesis and includes compounds active in the nervous and …
is not committed to protein synthesis and includes compounds active in the nervous and …
The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders
TW Stone, LG Darlington - British journal of pharmacology, 2013 - Wiley Online Library
Understanding the neurochemical basis for cognitive function is one of the major goals of
neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range …
neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range …
Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia
KR Linderholm, E Skogh, SK Olsson… - Schizophrenia …, 2012 - academic.oup.com
Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on
studies showing increased brain levels of KYNA in patients. KYNA is an endogenous …
studies showing increased brain levels of KYNA in patients. KYNA is an endogenous …
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder
ME Sublette, HC Galfalvy, D Fuchs, M Lapidus… - Brain, behavior, and …, 2011 - Elsevier
BACKGROUND: Inflammation has been linked to depression and suicide risk. One
inflammatory process that has been minimally investigated in this regard is cytokine …
inflammatory process that has been minimally investigated in this regard is cytokine …
Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression
RC Shelton, AH Miller - Progress in neurobiology, 2010 - Elsevier
Obesity and related metabolic conditions are of epidemic proportions in most of the world,
affecting both adults and children. The accumulation of lipids in the body in the form of white …
affecting both adults and children. The accumulation of lipids in the body in the form of white …
Reduction of brain kynurenic acid improves cognitive function
R Kozak, BM Campbell, CA Strick… - Journal of …, 2014 - Soc Neuroscience
The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute
to core symptoms arising from glutamate hypofunction, including cognitive impairments …
to core symptoms arising from glutamate hypofunction, including cognitive impairments …
L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences
H Fujigaki, Y Yamamoto, K Saito - Neuropharmacology, 2017 - Elsevier
The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …
The role and mechanism of tryptophan–kynurenine metabolic pathway in depression
X Gong, R Chang, J Zou, S Tan… - Reviews in the …, 2023 - degruyter.com
Major depressive disorder (MDD) is a common mental illness characterized by persistent
low mood and anhedonia, normally accompanied with cognitive impairment. Due to its rising …
low mood and anhedonia, normally accompanied with cognitive impairment. Due to its rising …