Identifying patterns and drivers of infectious disease dynamics across multiple scales is a
fundamental challenge for modern science. There is growing awareness that it is necessary …

Symbiotic interactions are indispensable for metazoan function, but their origin and
evolution remain elusive. We use a controlled evolution experiment to demonstrate the …

Studies on the ecology and evolution of infectious diseases have expanded at an increasing
rate over the last several decades (fig. 1). This interest seems to have originally stemmed …

Infected hosts may preserve fitness by resisting parasites (reducing parasite burden) and/or
tolerating them (preventing or repairing infection-induced damage). Theory predicts that …

Adaptation in nature is ubiquitous, yet characterizing its genomic basis is difficult because
population demographics cause correlations with nonadaptive loci. Introduction events …

Abstract Species of Eimeria (Apicomplexa: Coccidia) differ in the timing of lifecycle
progression and resulting infections vary in host immune reactions and pathology they …

The majority of organisms host multiple parasite species, each of which can interact with
hosts and competitors through a diverse range of direct and indirect mechanisms. These …

Virus-host coevolution has selected for generalized host defense against viruses,
exemplified by interferon production/signaling and other innate immune function in …

Reduced genetic variation among hosts may favour the emergence of virulent infectious
diseases by enhancing pathogen replication and its associated virulence due to adaptation …

Abstract The 7-benzylidenenaltrexone (BNTX) derivatives 2a–v, 3a–c, 13a–c, and 14a were
synthesized from naltrexone (1) and evaluated for their antitrichomonal activity. The structure …