Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
The end of AIDS: HIV infection as a chronic disease
The success of antiretroviral therapy has led some people to now ask whether the end of
AIDS is possible. For patients who are motivated to take therapy and who have access to …
AIDS is possible. For patients who are motivated to take therapy and who have access to …
International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
Point of care testing for infectious diseases
Infectious diseases are caused by pathogenic microorganisms and can be transmitted
between individuals and populations thus threatening the general public health and …
between individuals and populations thus threatening the general public health and …
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
R Fromentin, W Bakeman, MB Lawani, G Khoury… - PLoS …, 2016 - journals.plos.org
HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART).
Identifying cellular markers expressed at the surface of these cells may lead to novel …
Identifying cellular markers expressed at the surface of these cells may lead to novel …
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
F Maldarelli, X Wu, L Su, FR Simonetti, W Shao, S Hill… - Science, 2014 - science.org
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
JB McBrien, M Mavigner, L Franchitti, SA Smith… - Nature, 2020 - nature.com
Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …
Immune clearance of highly pathogenic SIV infection
SG Hansen, MP Jr, AB Ventura, CM Hughes… - Nature, 2013 - nature.com
Established infections with the human and simian immunodeficiency viruses (HIV and SIV,
respectively) are thought to be permanent with even the most effective immune responses …
respectively) are thought to be permanent with even the most effective immune responses …
Absence of detectable HIV-1 viremia after treatment cessation in an infant
D Persaud, H Gay, C Ziemniak, YH Chen… - … England Journal of …, 2013 - Mass Medical Soc
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection
began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure …
began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …