5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

It is evident that in the last decade or so, a vast amount of new information has become
available concerning the various 5-HT receptor types and their characteristics. This derives …

Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are
mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family …

Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
antidepressant class today and exert their antidepressant-like effects by increasing synaptic …

Serotonergic hallucinogens produce profound changes in perception, mood, and cognition.
These drugs include phenylalkylamines such as mescaline and 2, 5-dimethoxy-4 …

Risperidone and its active metabolite 9-OH-risperidone were compared to reference
antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and …

The distribution of serotonin-1 (5-HT 1) receptors in the rat brain was studied by light
microscopic quantitative autoradiography. Receptors were labeled with [3 H] serotonin (5-[3 …

The effects of serotonin on pyramidal cells of layer V of the medial prefrontal cortex were
examined using intracellular recording techniques in rat brain slices in vitro. Bath …