Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

In this chapter, we describe the impact and etiology of chronic pain, the associated changes
in the nervous system, and the mechanisms by which exercise may be able to affect and …

Introduction: Most arthritides are associated with pain and psychological distress (clinically
significant depression and anxiety). Pain and depression are mutually exacerbating; both …

Chronic pain is a major socioeconomic burden globally. The most frequent origin of chronic
pain is musculoskeletal. In inflammatory musculoskeletal diseases such as rheumatoid …

Background Pain is a predominant symptom in rheumatoid arthritis (RA) patients that results
from joint inflammation and is augmented by central sensitization. Regulator of G-protein …

Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of …

Background Pain remains a prevalent symptom for rheumatoid arthritis (RA) patients despite
a wide therapeutic choice. The objective of this study was to provide a multidimensional …

Objective This study explored the role of central sensitization (CS) pain in patients with
various rheumatic diseases using the CS inventory (CSI). Methods A total of 193 patients of …

The purpose of the study was to assess the proportion of patients who achieve pain relief
thresholds, the time needed to reach the thresholds, and the relationship between pain and …